Hydroxyurea induced non-healing leg ulcer.

نویسندگان

K Prabhash

P P Bapsy

چکیده

Damage to the supporting structures, disruption of the cementing substance binding the nail plate to the surrounding structures or formation of granular layer, which is otherwise absent in a normal nail bed and nail matrix, will produce onycholysis. Trauma from physical factors, manicuring, foreign body implantation or chemicals like solvents, various nail cosmetics and immersion in alkaline soap water etc. will cause onycholysis in occupation-related cases. Psoriasis, lichen planus, eczemas, pemphigus, Darier’s disease, leprosy, scleroderma, bacterial, fungal or viral infections and congenital ectodermal defects are some of the dermatological diseases associated with onycholysis. It may also be secondary to general medical conditions like hypo-or hyperthyroidism, porphyrias, syphilis, peripheral ischemia, bronchiectasis, anemia and pregnancy. Drugs like tetracyclines, psoralens, fluoroquinolones and phenothiazines may produce photoonycholysis while adriamycin, bleomycin, 5 – fluorouracil, cephaloridine and cloxacillin cause onycholysis through toxicity to nail matrix or nail bed. Benign or malignant tumors underneath the nail plate may also present clinically with onycholysis. However, most cases of onycholysis remain idiopathic.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Reversible leg ulcer due to hydroxyurea in a case of chronic myeloid leukemia.

The cutaneous side effects of hydroxyurea are lesser known complication of long term hydroxyurea therapy in myeloproliferative disorders. We report a non-diabetic patient, who developed hydroxyurea dermopathy (leg ulcers) during long-term treatment with hydroxyurea for chronic myeloid leukemia (CML). The time course of the development of ulcers and its healing suggests that these resulted from ...

متن کامل

A case of hydroxyurea-induced leg ulcer after definitive treatment suspension in a patient affected by thrombocythemia: effectiveness of a new collagenase.

Hydroxyurea (HU) is an antitumor agent effective in the treatment of myeloproliferative disorders. It is usually well-tolerated and has low toxicity but its use is associated with several adverse cutaneous effects. Among them, leg ulcers have been noted in association with long-term administration. Poor response to traditional local and systemic therapy is a typical feature of HU-induced leg ul...

متن کامل

Hydroxyurea associated leg ulcer succesfully treated with hyperbaric oxygen in a diabetic patient.

Oxygen tension in healing tissues is heterogeneous. Increased oxygen mostly stimulates repair mechanisms and enhances tissue healing. Hyperbaric oxygen therapy increases blood and tissue oxygen content and may help maintain cellular integrity and function. Hydroxyurea (HU) is a cytotoxic agent, which leads to inactivation of ribonucleotide reductase, inhibition of cellular DNA synthesis, and ce...

متن کامل

A Hydroxyurea-induced Leg Ulcer.

Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration,...

متن کامل